Introduction.The therapeutic approach of deep carious lesions in the temporary teeth represents an extremely complex problem for pediatric dentists, both in terms of their instrumentation and in terms of collaboration with children in specialized treatment, but also with their parents.Purpose.In this material we tried to present as briefly as possi
BACKGROUND: Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into adipocytes, osteoblasts and other cells.The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the mechanisms remain largely unknown.METHODS AND FINDINGS: We report that activation of PKA by 3-isobutyl-1
Zancong Shen, Colin Rowlings, Brad Kerr, Vijay Hingorani, Kimberly Manhard, Barry Quart, Li-Tain Yeh, Chris Storgard Ardea Biosciences, Inc.(a member of the AstraZeneca group), San Diego, CA, USA Abstract: Lesinurad is a selective uric trm atom knife acid reabsorption inhibitor under investigation for the treatment of gout.Single and multiple ascen
Engineering design optimization problems are difficult to solve because the objective function is often complex, with a mix of continuous and discrete design variables and various design constraints.Our research presents a novel hybrid algorithm that integrates the benefits of the sine cosine algorithm (SCA) and artificial bee colony (ABC) to addre